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Effects of Vaccine Combinations against Mycoplasma gallisepticum on Egg Characteristics of Commercial Layer Chickens

26 May 2015

Poultry Science journal

A new study at Mississippi State University reveals that one or two selected vaccines against Mycoplasma gallisepticum (MG) can be administered to pullets at 10 weeks of age and a further vaccination at 45 weeks of age without adversely affecting eqq quality.

Live F-strain Mycoplasma gallisepticum (FMG) vaccines are presently being used to help control field-strain MG outbreaks. However, they may exert some adverse effects on egg production, report D. Peebles and colleagues at Mississippi State University in a paper in the current edition of Poultry Science.

They explain that live strains of MG of lesser virulence as well as killed vaccines have little or no effect on egg production but that they afford lower levels of protection. This has led to research investigating their use in combination with a subsequent overlay vaccination of FMG given later in the production cycle.

In their present study, two trials were conducted to investigate the effects of pre-lay vaccinations of live and killed MG vaccines or their combination, in conjunction with an FMG vaccine overlay after peak production, on the egg characteristics of commercial layers.

The following vaccination treatments were administered at 10 weeks of age:

  1. unvaccinated (Control)
  2. MG-Bacterin (MGBac) vaccine
  3. ts-11 strain MG (ts11MG) vaccine, and
  4. MGBac and ts11MG combination (MGBac + ts11MG).

At 45 weeks of age, half of the birds were overlaid with an FMG vaccine.

In each trial, internal egg and eggshell parameters including egg weight (EW), Haugh unit score (HU), eggshell breaking strength (EBS), percentage yolk weight (PYW), percentage albumen weight (PAW), percentage eggshell weight (PSW), eggshell weight per unit surface area (SWUSA), percentage yolk moisture (PYM) and percent total lipids (PYL) were determined at various time periods between 21 and 52 weeks of age.

At 28 weeks of age, SWUSA was lower in the ts11MG and MGBac + ts11MG groups than in the control group.

Conversely, at 43 weeks of age, SWUSA was higher in the ts11MG than in the MGBac group.

Between 23 and 43 weeks of age, PYL was higher in the MGBac and ts11MG groups than in the control group.

Peebles and co-authors concluded that vaccination with MGBac alone or in combination with ts11MG at 10 weeks of age – with or without an FMG vaccine overlay at 45 weeks of age – does not adversely affect the internal egg or eggshell quality of commercial layers throughout lay.


Jacob R., S.L. Branton, J.D. Evans, S.A. Leigh and E.D. Peebles. 2015. Effects of different vaccine combinations against Mycoplasma gallisepticum on the internal egg and eggshell characteristics of commercial layer chickens. Poultry Science. 94:912-917.

Further Reading

You can view the full report by clicking here.
Find out more about Mycoplasma gallisepticum in poultry by clicking here.

May 2015

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