Elevated Risk of Carrying Gentamicin-Resistant Escherichia coli among U.S. Poultry Workers

By Lance B. Price, Jay P. Graham, Leila G. Lackey, Amira Roess, Rocio Vailes, and Ellen Silbergeld researchers at The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. Antimicrobial use in food-animal production is an issue of growing concern.

4 January 2008

3 minute read

The application of antimicrobials for therapy, prophylaxis, and growth promotion in broiler chicken production has been associated with the emergence and dissemination of antimicrobial-resistant enteric bacteria.

Although human exposure to antimicrobial-resistant bacteria through food has been examined extensively, little attention has been paid to occupational and environmental pathways of exposure.

Objective

The objective of the study was to measure the relative risk for colonisation with antimicrobial-resistant Escherichia coli among poultry workers compared with community referents.

Methods

The research team collected stool samples and health surveys from 16 poultry workers and 33 community referents in the Delmarva region of Maryland and Virginia. E. coli was cultured from stool samples, and susceptibility to ampicillin, ciprofloxacin, ceftriaxone, gentamicin, nitrofurantoin, and tetracycline was determined for each E. coli isolate.

The researchers estimated the relative risk for carrying antimicrobial-resistant E. coli among poultry workers compared with community referents.

Results

Poultry workers had 32 times the odds of carrying gentamicin-resistant E. coli compared with community referents.

The poultry workers were also at significantly increased risk of carrying multidrug-resistant E. coli.

Conclusions

Occupational exposure to antimicrobial-resistant E. coli from live-animal contact in the broiler chicken industry may be an important route of entry for antimicrobial-resistant E. coli into the community. Key words antibiotic, antimicrobial, aminoglycoside, chickens, Escherichia coli, gentamicin, occupational exposure, poultry, resistance, worker.