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Researchers Uncover Novel Mycotoxin Treatment

07 May 2013

ROMANIA - Researchers in Iasi have found that the berries of the sea buckthorn protected the liver of chickens with aflatoxin B1 poisoning.

The leaves and berries of sea buckthorn (SB; Hippophae rhamnoides ; family Elaeagnaceae ) are medically claimed as having phyto-antioxidant, anti-inflammatory and anti-cancerous properties in humans, according to Carmen Solcan from the University of Agricultural Sciences and Veterinary Medicine in Iasi and co-authors there and at Gr. T. Popa University of Medicine and Pharmacy, also in Iasi.

Their findings, published in Poultry Science recently, suggest that SB oil has a potent hepatoprotective activity, reducing the concentration of aflatoxins in liver and diminishing their adverse effects in broilers.

This study evaluated the hepatoprotective activity of oil from SB berries against toxicity induced by aflatoxin B1 (AFB1) in broiler chickens.

The toxicity of AFB1 led to lower total serum proteins and specifically reduced albumin (P<0.001). Serum aspartate amino-transferase increased from 191.14 ± 11.56 to 218.80 ±13.68 (P<0.001).

When chickens were simultaneously dosed with AFB1 and an extract of SB berries, subsequent histology of the liver showed a significant reduction of necrosis and fatty formation compared with chickens treated with AFB1 alone.

Immunohistochemical results indicated that COX2, Bcl-2, and p53 were highly expressed in the liver of AFB1-treated chickens and their expression was significantly reduced by SB oil supplementation.

The levels of AFB1 residues in chickens livers were significantly reduced by SB oil from 460.92 ± 6.2ng per mL in the AFB1 group to 15.59 ± 6.1ng per mL in the AFB1 and SB oil group.


Solcan C., M. Gogu, V. Floristean, B. Oprisan and G. Solcan. 2013. The hepatoprotective effect of sea buckthorn (Hippophae rhamnoides) berries on induced aflatoxin B1 poisoning in chickens. Poult. Sci. 92(4): 966-974. doi: 10.3382/ps.2012-02572


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