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Book Contents

Histopathology and Cytology of
Poultry Diseases
By Ivan Dinev, DVM, PhD


MYELOCYTOMATOSIS

Fig. 1. Myelocytomatosis (MC) is characterized
by proliferation of immature
cells from the granulocyte order
– myelocytes and promyelocytes. It
has an aleukaemic character. Occurs
independently or in association with
a number of other neoplastic diseases.
Atypical morphological forms
are possible. Histologically, myelocytomas
are easily distinguinshed. Most
commonly, they have a perivascular
localization. Growth of myelocytes
with a relatively high degree of maturity
and well formed eosinophilic
granules in a liver cross-section. H/E,
Bar = 50 µm.

Fig. 1. Myelocytomatosis (MC) is characterized by proliferation of immature cells from the granulocyte order – myelocytes and promyelocytes. It has an aleukaemic character. Occurs independently or in association with a number of other neoplastic diseases. Atypical morphological forms are possible. Histologically, myelocytomas are easily distinguinshed. Most commonly, they have a perivascular localization. Growth of myelocytes with a relatively high degree of maturity and well formed eosinophilic granules in a liver cross-section. H/E, Bar = 50 µm.

 
Fig. 2. Atrophic degenerative alterations
resulting from compression in a
case of intensive myelocyte proliferation
in the liver. H/E, Bar = 40 µm.

Fig. 2. Atrophic degenerative alterations resulting from compression in a case of intensive myelocyte proliferation in the liver. H/E, Bar = 40 µm.

 
Fig. 3. Focal intertubular myelocyte
proliferations in the kidney. H/E, Bar
= 25 µm.

Fig. 3. Focal intertubular myelocyte proliferations in the kidney. H/E, Bar = 25 µm.

 
Fig. 4. Numerous myelocytes in the
peripheral blood of a guineafowl
keet, 95 days after challenge with
an ALV-J isolate. H/E, Bar = 10 µm.

Fig. 4. Numerous myelocytes in the peripheral blood of a guineafowl keet, 95 days after challenge with an ALV-J isolate. H/E, Bar = 10 µm.

 
Fig. 5. Blood smear from a hen with
myelocytomatosis. A picture of anaemia
– anisocytosis, poikilocytosis,
two-nucleus erythrocyte (arrow).
H/E, Bar = 10 µm.

Fig. 5. Blood smear from a hen with myelocytomatosis. A picture of anaemia – anisocytosis, poikilocytosis, two-nucleus erythrocyte (arrow). H/E, Bar = 10 µm.

 
Fig. 6. Blood smear from a hen with
myelocytomatosis. A picture of anaemia
– anisocytosis, poikilocytosis,
erythrocyte without nucleus (arrow).
H/E, Bar = 10 µm.

Fig. 6. Blood smear from a hen with myelocytomatosis. A picture of anaemia – anisocytosis, poikilocytosis, erythrocyte without nucleus (arrow). H/E, Bar = 10 µm.

 

MYELOCYTOMATOSIS - ASSOCIATED NEOPLASMS

Fig. 7. Rhabdomyosarcoma, pectoral
muscle, hen. An extremely high
polymorphism of cells constituting
tumour parenchyma. H/E, Bar = 25
µm.

Fig. 7. Rhabdomyosarcoma, pectoral muscle, hen. An extremely high polymorphism of cells constituting tumour parenchyma. H/E, Bar = 25 µm.

 
Fig. 8. Rhabdomyosarcoma located
in the thigh muscle of a hen. An area
with multiple hyperchromatic, polynuclear
cells. H/E, Bar = 25 µm.

Fig. 8. Rhabdomyosarcoma located in the thigh muscle of a hen. An area with multiple hyperchromatic, polynuclear cells. H/E, Bar = 25 µm.

 
Fig. 9. Leiomyosarcoma, mesosalpinx.
Polygonal giant cells with hyperchromatic
nuclei. H/E, Bar = 25 µm.

Fig. 9. Leiomyosarcoma, mesosalpinx. Polygonal giant cells with hyperchromatic nuclei. H/E, Bar = 25 µm.

 
Fig. 10. Leiomyosarcoma, small intestine.
Prolongations of polynuclear
symplastic elements (arrows). H/E,
Bar = 30 µm

Fig. 10. Leiomyosarcoma, small intestine. Prolongations of polynuclear symplastic elements (arrows). H/E, Bar = 30 µm

 
Fig. 11. Leiomyosarcoma, small intestine.
Extraordinary (“monstrous”)
multinuclear giant cell with intracytoplasmic
vacuoles. H/E, Bar = 25 µm.

Fig. 11. Leiomyosarcoma, small intestine. Extraordinary (“monstrous”) multinuclear giant cell with intracytoplasmic vacuoles. H/E, Bar = 25 µm.

 
Fig. 12. Degenerative necrobiotic
process of a leiomyosarcoma metastasis
in the liver of a hen. H/E, Bar =
25 µm.

Fig. 12. Degenerative necrobiotic process of a leiomyosarcoma metastasis in the liver of a hen. H/E, Bar = 25 µm.

 
Fig. 13. Myxosarcoma, liver, hen. H/E,
Bar = 25 µm.

Fig. 13. Myxosarcoma, liver, hen. H/E, Bar = 25 µm.

 
Fig. 14. Fibro-myxosarcoma, metastatic
focus in the cervical subcutis
from a primary mixed mesenchymal
tumour in the alimentary tract. H/E,
Bar = 40 µm.

Fig. 14. Fibro-myxosarcoma, metastatic focus in the cervical subcutis from a primary mixed mesenchymal tumour in the alimentary tract. H/E, Bar = 40 µm.

 
Fig. 15. Carcinosarcoma, pancreas.
Tubulous glandular epithelial formations
- carcinomatous component
(arrow), among the liposarcomatous
part of the parenchyma. H/E, Bar =
30 µm.

Fig. 15. Carcinosarcoma, pancreas. Tubulous glandular epithelial formations - carcinomatous component (arrow), among the liposarcomatous part of the parenchyma. H/E, Bar = 30 µm.

 
Fig. 16. Carcinosarcoma in the region
of the infraorbital sinus. Adeno- (a)
and cystadenocarcinomatous (ca)
structures among the sarcomatous
part of the parenchyma. H/E, Bar =
30 µm.

Fig. 16. Carcinosarcoma in the region of the infraorbital sinus. Adeno- (a) and cystadenocarcinomatous (ca) structures among the sarcomatous part of the parenchyma. H/E, Bar = 30 µm.

 
Fig. 17. Nephroblastoma. An area of
embryonal-like cells of mesenchymal
and epithelial origin. Simultaneous
presence of tubules (arrow) at a different
stage of development. Young
nondifferentiated tubules are not
clearly distinguished among the sarcomatous
structures. H/E, Bar = 30
µm.

Fig. 17. Nephroblastoma. An area of embryonal-like cells of mesenchymal and epithelial origin. Simultaneous presence of tubules (arrow) at a different stage of development. Young nondifferentiated tubules are not clearly distinguished among the sarcomatous structures. H/E, Bar = 30 µm.

 
Fig.18. Nephroblastoma. A group
of poorly differentiated glomerular
structures among the neoplastic tissue
of a fibrous type. H/E, Bar = 50 µm.

Fig.18. Nephroblastoma. A group of poorly differentiated glomerular structures among the neoplastic tissue of a fibrous type. H/E, Bar = 50 µm.

 
Fig. 19. Nephroblastoma. Young tubules
with a rosette-like structure.
H/E, Bar = 50 µm.

Fig. 19. Nephroblastoma. Young tubules with a rosette-like structure. H/E, Bar = 50 µm.

 
Fig. 20. Kidney, cystadenocarcinoma.
H/E, Bar = 35 µm.

Fig. 20. Kidney, cystadenocarcinoma. H/E, Bar = 35 µm.

 
Fig. 21. Ovary, granulosa-theca cell
tumour. Islets of anaplastic cells, delineated
by well-developed stroma
of fibrous and smooth muscle fibres.
H/E, Bar = 30 µm.

Fig. 21. Ovary, granulosa-theca cell tumour. Islets of anaplastic cells, delineated by well-developed stroma of fibrous and smooth muscle fibres. H/E, Bar = 30 µm.

 
Fig. 22. Ovary, granulosa-theca cell
tumour. Tubulus-like formations (arrow)
of the tumour parenchyma.
H/E, Bar = 25 µm.

Fig. 22. Ovary, granulosa-theca cell tumour. Tubulus-like formations (arrow) of the tumour parenchyma. H/E, Bar = 25 µm.

 
Fig. 23. Haemangiosarcoma of the
small intestinal wall. The parenchyma
consists of anastomizing canals with
papilliferous depressions. H/E, Bar =
50 µm.

Fig. 23. Haemangiosarcoma of the small intestinal wall. The parenchyma consists of anastomizing canals with papilliferous depressions. H/E, Bar = 50 µm.

 
Fig. 24. Liver cell carcinoma. Growth
of rosette-like and tubulous structures
(a) surrounded by a dense fibrous
and well-vascularized capsule.
H/E, Bar = 50 µm.

Fig. 24. Liver cell carcinoma. Growth of rosette-like and tubulous structures (a) surrounded by a dense fibrous and well-vascularized capsule. H/E, Bar = 50 µm.

 
Fig. 25. Cholangioma, liver, hen. Well
differentiated structures resembling
biliary ducts. H/E, Bar = 35 µm.

Fig. 25. Cholangioma, liver, hen. Well differentiated structures resembling biliary ducts. H/E, Bar = 35 µm.

 
Fig. 26. Intrahepatic cholangiocarcinoma.
Irregular glandular papilliferous
neoplastic formations. Marked
stromal desmoplasia. Fibrous tissue
surrounding the neoplastic glands.
H/E, Bar = 50 µm.

Fig. 26. Intrahepatic cholangiocarcinoma. Irregular glandular papilliferous neoplastic formations. Marked stromal desmoplasia. Fibrous tissue surrounding the neoplastic glands. H/E, Bar = 50 µm.

 
Fig. 27. Extrahepatic cholangiocarcinoma.
Glandular epithelial carcinoma
to the extrahepatic biliary tract. H/E,
Bar = 25 µm.

Fig. 27. Extrahepatic cholangiocarcinoma. Glandular epithelial carcinoma to the extrahepatic biliary tract. H/E, Bar = 25 µm.

 
Fig. 28. Glioblastoma, symmetrical
neoplastic foci, brain, hen. H/E, Bar
= 35 µm.

Fig. 28. Glioblastoma, symmetrical neoplastic foci, brain, hen. H/E, Bar = 35 µm.

 
This book is protected by the copyright law. The reproduction, imitation or distribution of the book in whole or in part, in any format (electronic, photocopies etc.) without the prior consent, in writing, of copyright holders is strictly prohibited.

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