Nobilis Gumboro 228E: power plus balance

In vaccination against Gumboro Disease, there are two conventional choices:

• Intermediate vaccines have few side effects, but limited efficacy against vvIBD in the field or in situations of high infectious pressure.
• Hot vaccines have a powerful and aggressive action, but can damage the bursa, impairing the immune response and response to other vaccinations.

Nobilis Gumboro 228E gives you a more balanced option an Intermediate Plus vaccine combining the power of a hot vaccine with the safety of an intermediate.

Unrivalled protection, without immuno-suppression

Nobilis Gumboro 228E has the power to breakthrough higher titres of maternally derived antibodies (MDA) than intermediate vaccines - but without immuno-suppression, as demonstrated by

• Extensive laboratory trials
• Pathological examination of the bursa
• Performance in Gumboro outbreaks, world-wide.

Nobilis Gumboro 228 E is a live vaccine against Infectious bursal disease (Gumboro) in chickens. Active components per dose:
- Live I.B.D. virus strain 228E &ge: 2.0 log¹⁰ EID₅₀ A freeze-dried pellet. Chickens. Immunization of chickens against Gumboro Disease (IBD). The vaccine virus strain 228E is a less attenuated intermediate IBDV strain. As a result of this, the virus is capable of breaking through the maternal immunity at an earlier stage and will spread better through the vaccinated flock. The age at which chickens can be successfully vaccinated depends on the level of maternally derived antibodies (MDA) and therefore on the type of birds and on the way the parent breeding flock is vaccinated.

Guideline:

• Broilers derived from parent flocks vaccinated with live Gumboro vaccines only, can be vaccinated from day 7-14.
• Broilers derived from parent flocks vaccinated with inactivated Gumboro vaccines, can be vaccinated from day 14-17.
• The vaccination of future laying stock derived from parent flocks vaccinated with live Gumboro vaccines only, can be carried out from day 14-21.
• The vaccination of future laying stock derived from parent flocks vaccinated with inactivated Gumboro vaccines, should be carried out from day 21-28.

The above scheme is based on the fact that during these periods the MDA levels in that particular progeny have decreased sufficiently (e.g. log2 VN titre between approximately 7.0 and 8.5) to be able to vaccinate them successfully with Nobilis Gumboro 228E but are still high enough to protect them against infection with circulating field virus. One dose per bird. Via the drinking water.
The vials should be opened under water. Use cool, clean water which is free of iron and chlorine. By adding 2 gram skimmed milk powder per litre of water the virus retains its activity much longer. Ensure uptake of all the vaccine-medicated water in 2 hours. Depending on the weather conditions, it may be advisable to deprive the birds of water prior to vaccination. A sufficient number of water containers to provide adequate drinking space is essential. These should be clean and free from traces of detergents and disinfectants. Dissolve 1000 doses in as many litres of water as the age of the birds in days, to a maximum of 40 litres. The vaccine should be given in the early morning as this is the main period for drinking or the cool period on a hot day. When vaccinating larger flocks, it is advisable to begin by dissolving only part of the vaccine. If vaccine is administered through a central water supply or a proportioner, great care should be taken. For numbers of birds between standard dosages, the next higher dosage should be chosen. None. Vials each containing 1000 or 2500 doses in packs of 10 vials. Store between 2-8°C in the dark.

• Wash and disinfect hands and equipment after vaccination.
• Vaccinate healthy birds only.
• Each vial should be used immediately after opening.

None.

• Do not combine with other vaccines unless specified on leaflet.
• Dispose of empty or part-used vials in accordance with local regulations.