Poulvac® Procerta™ HVT-ND fully protects against Newcastle disease by 19 days of age

Rigorous research and the application of cutting-edge technology by Zoetis scientists were behind the development of the newest recombinant vaccine to protect broilers from Newcastle and Marek’s disease viruses.
calendar icon 22 June 2020
clock icon 6 minute read
By: Zoetis

Compatible with Poulvac Bursaplex®

US poultry producers are acutely aware that the ND virus is an extremely contagious respiratory disease that can result in mortality, she continued. MD causes immune suppression that predisposes broilers to secondary infections, and it’s an important cause of condemnations.

“However, another major concern is infectious bursal disease (IBD), which prompted us to make sure the new vectored HVT-ND vaccine can be administered with Poulvac Bursaplex®, a classic, live viral vaccine with complexed antibodies,” Rong said.

In two separate studies, SPF leghorns received Poulvac Procerta HVT-ND along with Poulvac Bursaplex, either in ovo or by subcutaneous injection on day of hatch, and were challenged with a velogenic strain of ND or with a virulent classic IBD virus.

Based on parameters including efficacy, serology, mortality and clinical observation, the vaccines were found to be compatible when administered together,8 she said.

As the use of antibiotics in broilers has declined, the importance of vaccination to establish immunity against viruses has increased because viruses not only make chickens sick, they predispose them to secondary bacterial infections, Rong emphasized.

“Poulvac Procerta HVT-ND provides a way to help flocks develop foundational immunity against ND without the reactions that can occur with live vaccines. That means less stress on birds, which is especially important when birds also need vaccination with live vaccines for protection against other diseases like infectious bronchitis as well as IBD,” she said.

The team demonstrated vaccine uptake by isolating HVT-ND viral DNA from feather pulp and analyzed it by two methods: quantitative real-time polymerase chain reaction (qPCR) assays and digital droplet PCR (ddPCR) (Figure 1),4 she said, and noted the feather-pulp ddPCR test provides a way to determine if the vaccine has been administered correctly.5

Although the onset of immunity was found to be 19 days of age, another study in commercial broilers showed there was a clear increase in the geometric mean antibody response to the vaccine as early as 10 days of age based on ELISA results,6 Rong said (Figure 2).

The vaccine’s high level of safety when administered by either route was demonstrated in field trials conducted in Arkansas, Georgia and Alabama. “Compared to controls, there were no significant differences in the percent of eggs hatched nor in broiler bodyweight or percent mortality or condemnations,”7 she said.

Compatible with Poulvac Bursaplex®

US poultry producers are acutely aware that the ND virus is an extremely contagious respiratory disease that can result in mortality, she continued. MD causes immune suppression that predisposes broilers to secondary infections, and it’s an important cause of condemnations.

“However, another major concern is infectious bursal disease (IBD), which prompted us to make sure the new vectored HVT-ND vaccine can be administered with Poulvac Bursaplex®, a classic, live viral vaccine with complexed antibodies,” Rong said.

In two separate studies, SPF leghorns received Poulvac Procerta HVT-ND along with Poulvac Bursaplex, either in ovo or by subcutaneous injection on day of hatch, and were challenged with a velogenic strain of ND or with a virulent classic IBD virus.

Based on parameters including efficacy, serology, mortality and clinical observation, the vaccines were found to be compatible when administered together,8 she said.

As the use of antibiotics in broilers has declined, the importance of vaccination to establish immunity against viruses has increased because viruses not only make chickens sick, they predispose them to secondary bacterial infections, Rong emphasized.

“Poulvac Procerta HVT-ND provides a way to help flocks develop foundational immunity against ND without the reactions that can occur with live vaccines. That means less stress on birds, which is especially important when birds also need vaccination with live vaccines for protection against other diseases like infectious bronchitis as well as IBD,” she said.

References
References
1 Luo Y, et al.
(2019.) Construction and efficacy of a recombinant HVT-ND vaccine against NDV and MDV challenges in SPF and NDV challenge in broiler birds.. Am Associat Avian Pathol.
2 Ibid.
3 Data on file. Study No.
Study No. B815W-US-18-964. Zoetis LLC. B815R-US-18-A46. Zoetis LLC.3a Data on file.
4 Bosserd M, et al.
(2019.) Onset of immunity of a recombinant HVT-ND against a velogenic NDV challenge in SPF birds.. Am Associat Avian Pathol.
5 Dimitrov K, et al.
(2017) Newcastle disease vaccines — A solved problem or a continuing challenge?. Vet Microbiol 2017;206:126-136.
6 Data on file.
Study No. B810W-US-16-700. Zoetis LLC
7 Data on file.
Study Nos. B911R-US-18-902, B911R-US-18-903, B911R-US-18-904 and B911R-US-18-906. Zoetis LLC.
8 Turner-Alston K, et al.
(2019.) Compatibility of a Recombinant HVT-ND Vaccine with Bursaplex to Provide Protection against Velogenic NDV and Virulent Classic IBDV Challenge in SPF Birds.. Am Associat Avian Pathol.
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