Evaluation of an IBD immune complex vaccine administered in ovo compared to an intermediate plus drinking water vaccine on a Belgian farm

Prevention of Infectious Bursal Disease (IBD) through vaccination can be achieved by different types of vaccines available on the market and by several routes of administration.
calendar icon 7 June 2021
clock icon 3 minute read
By: Hipra

On the farm studied, GUMBOHATCH® showed superior protection compared to an intermediate plus drinking water vaccine, as demonstrated by higher titres to the IBD virus and the absence of wild strains. Safety parameters were similar.

Conclusions

Gumboro live vaccines allow the vaccine viruses to reach the bursa of Fabricius and achieve the prized immunity by competitive exclusion. For optimal results, the vaccine virus should arrive at the right time for each chick, which it is not always possible to achieve with simple live vaccines. This trial reinforces the advantages of GUMBOHATCH®, a next-generation immune-complex IBD vaccine for hatchery application, compared to a reference live vaccine administered in drinking water.

Figure: serological response (A), bursa to body weight (B, least squares means ± 95% confidence interval) and macroscopic bursal lesions (C) after vaccination with GUMBOHATCH® or a reference vaccine.
Figure: serological response (A), bursa to body weight (B, least squares means ± 95% confidence interval) and macroscopic bursal lesions (C) after vaccination with GUMBOHATCH® or a reference vaccine.

On the farm studied, GUMBOHATCH® showed superior protection compared to an intermediate plus drinking water vaccine, as demonstrated by higher titres to the IBD virus and the absence of wild strains. Safety parameters were similar.

Conclusions

Gumboro live vaccines allow the vaccine viruses to reach the bursa of Fabricius and achieve the prized immunity by competitive exclusion. For optimal results, the vaccine virus should arrive at the right time for each chick, which it is not always possible to achieve with simple live vaccines. This trial reinforces the advantages of GUMBOHATCH®, a next-generation immune-complex IBD vaccine for hatchery application, compared to a reference live vaccine administered in drinking water.

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