Why live ND vaccines are NOT the best choice in high ND challenge countries

Regarding serology, only 31% of the birds vaccinated with the conventional program showed protective antibody levels (HI titre > 3 log2), while 100% of the birds vaccinated with Vectormune® ND showed protective levels of antibodies.

Analyzing broiler performances, the Vectormune® ND group showed an improvement in the productive parameters compared to the group vaccinated with the conventional program.

Vectormune® ND group showed an improvement of:

  • 21 points in EPEF
  • 3.3% better livability
  • 1.2 Kg more of meat / m2 (54 tons extra meat for 1 million birds)

Vaccination Program

Vectormune® ND program

Conventional Live program

Number of Birds

1.07 Million Birds

1.06 Million Birds

% birds of HI test >3 at Day 43

100%

31%

Livability %

96,3

93

Meat Kg/m²

54.2 Meat/m²

53 Meat/m²

European Index

353

332

Conclusion

  • Histological analysis of the trachea revealed the negative impact of repeated applications of La Sota vaccine. These Post Vaccination Reactions (PVR) are likely to affect the trachea health and facilitate respiratory outbreaks. This can also be a predisposition factor for any other pathogen leading to complicated respiratory diseases.
  • Vectormune® ND is decreasing the intensity of La Sota vaccine Post vaccination reaction and decreasing the number of respiratory outbreaks.
  • Vectormune® ND also minimizes the ND virus transmission.
  • Vectormune® ND group showed a better immune response level measured with HI tests which is evidencing a more consistent immunization.
  • Vectormune® ND group, showed stronger economical results Livability, European index, Meat kg / m² (parameters requested by the customer).
Score 0 = No inflammatory lesion. Rare Lymphocytes and Plasmocytes. No congestion.
Score 0 = No inflammatory lesion. Rare Lymphocytes and Plasmocytes. No congestion.
Score 1 = Light Inflammatory lesions. Spots of lymphocytes and Plasmocytes. Light congestion.
Score 1 = Light Inflammatory lesions. Spots of lymphocytes and Plasmocytes. Light congestion.
Score 2 = Moderate inflammatory lesions. Lymphocytes and plasmocytes invasion inducing thickening spots around the trachea wall.
Score 2 = Moderate inflammatory lesions. Lymphocytes and plasmocytes invasion inducing thickening spots around the trachea wall.
Score 3 =Severe Inflammatory lesions. Lymphocytes and plasmocytes invasion inducing thickening all around the trachea wall.
Score 3 =Severe Inflammatory lesions. Lymphocytes and plasmocytes invasion inducing thickening all around the trachea wall.

At 43 days of age, , a serological HI test study was carried out and an economic evaluation of both groups was analyzed.

Results

The conventional vaccine program birds, clearly showed a higher level of inflammatory lesions both in the upper and lower tract of the trachea than in the group of birds also vaccinated with Vectormune® ND.

Vectormune® ND program. Average Score: 0.86.
Vectormune® ND program. Average Score: 0.86.
Conventional group. Average Score: 1.86.
Conventional group. Average Score: 1.86.
Vectormune® ND program. Average Score: 0.46.
Vectormune® ND program. Average Score: 0.46.
Conventional program. Average Score: 1.26.
Conventional program. Average Score: 1.26.

Regarding serology, only 31% of the birds vaccinated with the conventional program showed protective antibody levels (HI titre > 3 log2), while 100% of the birds vaccinated with Vectormune® ND showed protective levels of antibodies.

Analyzing broiler performances, the Vectormune® ND group showed an improvement in the productive parameters compared to the group vaccinated with the conventional program.

Vectormune® ND group showed an improvement of:

  • 21 points in EPEF
  • 3.3% better livability
  • 1.2 Kg more of meat / m2 (54 tons extra meat for 1 million birds)

Vaccination Program

Vectormune® ND program

Conventional Live program

Number of Birds

1.07 Million Birds

1.06 Million Birds

% birds of HI test >3 at Day 43

100%

31%

Livability %

96,3

93

Meat Kg/m²

54.2 Meat/m²

53 Meat/m²

European Index

353

332

Conclusion

  • Histological analysis of the trachea revealed the negative impact of repeated applications of La Sota vaccine. These Post Vaccination Reactions (PVR) are likely to affect the trachea health and facilitate respiratory outbreaks. This can also be a predisposition factor for any other pathogen leading to complicated respiratory diseases.
  • Vectormune® ND is decreasing the intensity of La Sota vaccine Post vaccination reaction and decreasing the number of respiratory outbreaks.
  • Vectormune® ND also minimizes the ND virus transmission.
  • Vectormune® ND group showed a better immune response level measured with HI tests which is evidencing a more consistent immunization.
  • Vectormune® ND group, showed stronger economical results Livability, European index, Meat kg / m² (parameters requested by the customer).

Mustafa Seçkin Sandikli

Global Marketing Manager at Ceva

Fernando Lozano, DVM

Global Veterinary Services Manager, Ceva

Jaime Sarabia, DVM

Global Veterinary Services Manager, Ceva

Christophe Cazaban, DVM

Poultry Scientific Director, Ceva

Mathilde Lecoupeur

Real-World Evidence Data Manager at Ceva
© 2000 - 2024 - Global Ag Media. All Rights Reserved | No part of this site may be reproduced without permission.