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New Research Identifies Potential Biomarkers of Gut Health in Broilers

05 August 2015
Novus International

US - Alternative grains, such as wheat, barley and rye which are high in non-starch polysaccharides (NSP), can have a substantial negative impact on monogastric digestion and animal performance.

Chickens have little or no intrinsic enzymes capable of hydrolysing these NSP, leading to restricted digestibility of feed ingredients and significant reductions in growth.

Undigested feed ingredients in the gut provide nutrients for bacteria overgrowth in the hind gut, which can lead to dysbacteriosis. High NSP diets have also been associated with bacterial diseases that have major economic implications in broiler chickens.

In a recent research study entitled “Identification of potential biomarkers for gut barrier failure in broiler chickens,” published in Frontiers in Veterinary Sciences, Novus International, Inc., and University of Arkansas researchers used coccidiosis over-vaccination to trigger a gut health challenge in broiler chickens fed a wheat–barley–rye diet.

The overall growth performance and feed efficiency were severely reduced by this gut barrier failure (GBF) model. The results of this study are in agreement with previous studies that concluded high NSP diets compromised growth performance in chickens.

The purpose of the study was not to determine the individual effects of diet ingredients or coccidia challenge, but rather to determine potential biomarkers that may be used to define GBF in future studies. Biomarkers could be useful to monitor poultry health and understand disease mechanisms.

“This research demonstrates Novus’s commitment to the understanding of basic physiological and metabolic processes in poultry,” commented Jeffery Escobar, Executive Manager of Physiology Research at Novus.

“The results of this study will allow scientists at Novus, academia, and other poultry researchers to perform better evaluations of gut health parameters and enhance the ability to test solutions, which can translate into safer poultry products for human consumption.”

To review the full study, visit this link. To learn more about Novus International, visit

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